艾美科健(AMICOGEN)是AMICO(=拉丁语中意为"朋友")+GEN(=Gene,
"基因")的合成词, 公司通过其核心技术即基因进化技术,
致力于成为促进人类可持续发展,
保护地球环境的“真正的朋友”。
艾美科健以独家的基因进化技术为基础(i DNA evolution TM)
开发出工业用·制药用特殊酶产品。
利用特殊酶开发出健康功能食品原料即新型生物材料、
蛋白质提炼用树脂,为人类的可持续发展和健康做贡献。
艾美科健从生物科技企业做起,将核心力量关注在R&D上,
以创新的技术和产品追求可持续增长。
为了提高企业价值和股东价值,
在健康保健·蛋白质提炼树脂等领域不断强化核心力量。
过去的20年来,艾美科健始终从可持续的观点出发,开发出致力于人类和环境的生物创新技术,
从事经营。
艾美科健将以环境健全性、社会责任性、可持续创新技术为基础,推动企业可持续发展。
艾美科健以差异化的R&D技术和品质管理能力
开发新的生物产品和健康保健食品原料。
WorkBeads™ 40/1000 ACT and WorkBeads 40/10 000 ACT are pre-activated resins
that enable easy and reliable coupling of proteins, peptides and low-molecular weight
substances for the preparation of customized chromatography resins or enzyme reactors.
The bromohydrin active group reacts with thiol, amino and hydroxyl groups.
Two different resin porosities are available to facilitate optimized coupling of ligands of
different sizes, or to optimize the prepared affinity resin for target molecules of different sizes.
• Easy and reliable coupling procedure
• Stable covalent linkage
• Suitable for coupling of ligands containing thiol, amino and hydroxyl groups
Resin description
WorkBeads are agarose-based chromatographic resins manufactured using a proprietary method
that results in porous beads with a tight size distribution and exceptional mechanical stability.
Agarose based matrices have been successfully used for decades in biotechnology,
from research to production scale purification, due to their exceptional compatibility with
biomolecules including proteins, peptides, nucleic acids and carbohydrates.
WorkBeads resins are designed for separations that require optimal capacity and purity.
WorkBeads 40/1000 ACT and WorkBeads 40/10 000 ACT pre-activated resins are
a reliable starting material for the preparation of customized chromatography resins.
Main characteristics of WorkBeads 40/1000 ACT and WorkBeads 40/10 000 ACT resins
| WorkBeads 40/1000 ACT | WorkBeads 40/10 000 ACT |
Target substance | Small molecules and peptides | Small molecules, peptides, proteins, e.g., Immunoglobulins |
Target groups | Thiol, amino, and hydroxyl groups | |
Matrix | Rigid, highly cross-linked agarose | |
Average particle size1 (Dv50) | 45 μm | |
Reactive groups | Bromohydrin | |
Exclusion limit | 1 x 106 kDa (globular proteins) | 10 x 106 kDa (globular proteins) |
Max flow rate (20 cm bed height and 5 Bar) | 700 cm/h | 700 cm/h |
Reactive-groups content | 250 μmol/ml | 150 μmol/ml |
Chemical stability | Buffers pH<8.5; | |
Chemical stability | Compatible with all standard aqueous buffers used for protein purification, | |
pH stability3 | 2 – 13 (after coupling) | |
Storage4 | 2 to 25 °C in 20 % ethanol |
1. The median particle size of the cumulative volume distribution.
2. Avoid substances containing thiol and amino groups.
Substances containing hydroxyl groups will only react if deprotonated.
The unreacted resin is generally stable in alcohols at neutral pH.
3. Agarose matrix and linker. Stability of the coupled substance may differ.
4. The choice of storage conditions for the coupled resin depends on the nature of the ligand.
Product List
Product name | Size/Volume | Article Number |
WorkBeads 40/1000 ACT | Bulk-Media - 50 mL | 40 400 001 |
Bulk-Media - 300 mL | 40 400 003 | |
Bulk-Media - 1 L | 40 400 010 | |
WorkBeads 40/10000 ACT | Bulk-Media - 50 mL | 40 450 001 |
Bulk-Media - 300 mL | 40 450 003 | |
Bulk-Media - 1 L | 40 450 010 |