AMICOGEN

특수효소

Specialty enzyme

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특수효소 - 제약용

AMK618

Immobilized cefadroxil acylase

Description
It produces cefadroxil from 7-ADCA (7-amino-3-deacetoxy-cephalosporanic acid) and HPGM (p-Hydroxyphenylglycine methyl ester). 

 

 

Standard

 Activitya

 180 U/g

 Size of immobilization support

 300~500㎛(>98%)

 Water content

 61%

 Enzyme assay

 aOne unit(U) represents the amount of enzyme required for producing 1㎛ol cefadroxil per min in 50mM K-phosphate buffer containing 20mM 7-ADCA and 40mM HPGM, pH 7.0 at 28℃.

 

 

 

Application

Cefadroxil production from 7-ADCA and HPGM

 

 

Storage temperature

4~10°C

 

 

Characteristics
·High production of cefadroxil
·Low degradation activity of cefadroxil and HPGM
·Fast enzyme reaction
·High stability
·High production rate of cefadroxil

 

 

Reaction condition

 pH

 7.5

 Temperature

 10°C

 Solvent

 Water

 7ADCA : PGM

 1:1.05

 Enzyme amount

(In comparison with 7ADCA)

 1:1.5

 

 

 

 

Scheme for enzyme reaction

673c2f371d2ded79a1a5a62819b7d86e_1526628 

 

 

Optimal reaction conditions

(Temperature, pH)

673c2f371d2ded79a1a5a62819b7d86e_1526628