AMICOGEN

특수효소

Specialty enzyme

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특수효소 - 제약용

AMK328

Immobilized cefaclor acylase

Description
It produces cefaclor from PGM (phenylglycine methyl ester) and 7-ACCA (7-aminodesacetoxymethyl-3-chloro-cephalosporanic acid).​

 

 

Standard

 Activitya

 85 U/g

 Size of immobilization support

 300~500㎛(>95%)

 Water content

 61%

 Enzyme assay

aOne unit (U) represents the amount of enzyme required for producing 1ol cefaclor per min in 50mM K-phosphate buffer containing 20mM 7-ACCA and 20mM PGM, pH 6.7 at 28℃.

 

 

 

Application
Cefaclor production

 

 

Storage temperature
4~10°C

 

 

Characteristics
·High production of cefaclor
·Low degradation activity of cefaclor and PGM
·Fast enzyme reaction
·High stability
·High production rate of cefaclor​

 

 

Reaction condition

 pH

 7.4~7.8

 Temperature

 10°C

 Solvent

 Water

 7ACCA : PGM

 1:1.1

 Enzyme amount

(In comparison with 7ACCA)

 1:1

 

 

 

Scheme for enzyme reaction

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Optimal reaction conditions
(Temperature, pH)

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