AMICOGEN

특수효소

Specialty enzyme

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특수효소 - 제약용

AMK218

Immobilized amoxicillin acylase

Description
It produces amoxicillin from 6-APA(6-aminopenicilanic acid) and HPGM(hydroxyphenylglycine methyl ester).

 

 

Standard

 Activitya

 100 U/g wet weight

 Size of immobilization support

 250~300μm (>95%)

 Water content

 62%

 Enzyme assay

 aOne unit (U) represents the amount of enzyme required for producing 1μmol amoxicillin per min in 50mM K-phosphate buffer containing 30mM
6-APA(6-aminopenicilanic acid) and 30mM HPGM(hydroxyphenylglycine methyl ester), pH 6.1, at 28℃

 

 

Application
Amoxicillin production from 6-APA and HPGM

 

 

Storage temperature
4~10°C

 

 

Characteristics
·Fast enzyme reaction
·High stability (reusable more than 600 cycles)
·High production rate of amoxicillin (more than 97.5%)​

 

 

Reaction condition

 pH

 6.2~6.3

 Temperature

 10~20°C

 Solvent

 Water

 6-APA:HPGM

 1:1.02~1.05

 Enzyme amount

(In comparison with 6-APA weight)

 1:1~1.5

 

 

 

Scheme for enzyme reaction

673c2f371d2ded79a1a5a62819b7d86e_1526622 

 

 

Optimal reaction conditions
(Temperature, pH)

673c2f371d2ded79a1a5a62819b7d86e_1526622